Interstitial tissue concentrations of cefpodoxime

Interstitial tissue concentrations of cefpodoxime.

Microdialysis is a technique that allows the measurement of concentrations of free antibiotic in tissue. The free antibiotic concentration is responsible for the antibacterial effect at the target site. We used microdialysis in animal and human studies to investigate the tissue penetration of cefpodoxime. In the animal study, total plasma and free muscle and lung concentrations of cefpodoxime w...

P-58: Mast Cells in Interstitial Tissue in The Testis of Male Rats Treated with Acyclovir

Background: Acyclovir (9-(2-hydroxyethoxymethyl) guanine) (ACV) is an acyclic nucleoside analogue that has shown a potent antiviral activity, and it is known to inhibit the replication of herpesviruses including herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), varicella- zoster virus (VZV), and Epstein-Barr virus (EBV) in cell cultures and in animals. ACV is khown to be toxic to gonads,t...

Interstitial gland tissue of mammalian ovary.

Antimicrobial tissue concentrations.

The clinical outcome of anti-infective treatment is determined by both PK and PD properties of the antibiotic. Only the free tissue concentrations of antibiotics at the target site, which are usually lower than the total plasma concentrations, are responsible for therapeutic effect. The free antibiotic concentrations at the site of action are a more appropriate PK input value for PK-PD analysis...

Postmortem tissue concentrations of olanzapine.

Twenty-eight cases from 2004-2007 involving olanzapine were analyzed at the San Diego County Medical Examiner's Office. Olanzapine was initially detected by gas chromatography coupled with mass spectrometry (GC-MS), and then confirmed by GC with a nitrogen-phosphorus detector. In cases where olanzapine was detected, concentrations in peripheral blood (PB), central blood (CB), liver, and vitreou...